Research Articles
Precision at the Limit: A Strategic Guide to Method Validation for Low-Concentration Analytes
This article provides a comprehensive framework for validating the precision of analytical methods at low concentration levels, a critical challenge for researchers and drug development professionals.
Quantifying Uncertainty in ISO 8192:2007 Toxicity Tests: A Guide to GUM, Monte Carlo, and Robust Bioassays
This article provides a comprehensive guide to the quantification of measurement uncertainty in the ISO 8192:2007 activated sludge respiration inhibition test, a critical bioassay for evaluating substance toxicity in biomedical...
Mastering CLSI EP17-A2: A Comprehensive Guide to Detection Capability Validation for Clinical Laboratories
This article provides a complete guide to the CLSI EP17-A2 protocol for evaluating detection capability in clinical laboratory measurement procedures.
Verifying Functional Sensitivity: A Practical Guide to Establishing Interassay Precision Profiles for Robust Bioanalytical Methods
This article provides a comprehensive guide for researchers and drug development professionals on verifying functional sensitivity through interassay precision profiles.
Mastering Baseline Drift: A Scientist's Guide to Stable Measurements in Sensitive Instruments
This comprehensive guide addresses the pervasive challenge of baseline drift in sensitive analytical instruments, a critical issue for researchers and drug development professionals seeking reliable data.
Strategies to Identify, Troubleshoot, and Overcome Non-Specific Binding in SPR Experiments
This article provides a comprehensive guide for researchers and drug development professionals tackling non-specific binding (NSB) in Surface Plasmon Resonance (SPR) experiments.
PCR Additives Demystified: A Scientist's Guide to Enhancing Sensitivity with DMSO, BSA, and Formamide
This article provides a comprehensive guide for researchers and drug development professionals on leveraging common PCR additives—DMSO, BSA, and formamide—to overcome challenges in amplification sensitivity, specificity, and yield.
Optimizing DNA Yield in Filter-Based Bioaerosol Sampling: A Comprehensive Guide for Biomedical Research
Filter-based sampling is a cornerstone for collecting airborne microbial DNA, crucial for public health surveillance, pathogen detection, and ecological studies.
Hot-Start PCR: Revolutionizing Specificity for Low-Concentration Sample Analysis
This article provides a comprehensive guide for researchers and drug development professionals on leveraging Hot-Start PCR to achieve superior amplification specificity and sensitivity with low-concentration nucleic acid samples.
Advanced DNA Concentration Methods for Low Yield Samples: A 2025 Guide for Researchers
This article provides a comprehensive guide for researchers and drug development professionals grappling with DNA concentration from low-yield and challenging samples.